Pathological study of chronic lobular hepatitis— with special reference to pathology, diagnostic criteria, etiology and pathogenesis on the basis of analysis of 25 liver biopsies

Wu Xiu-gan; Liu Shao-chun; Zhang Xiao-jing; Hu Zong-yi

doi:10.1007/BF02911613

Current Medical Science ›› 1986, Vol. 6 ›› Issue (1) : 21 -25. DOI: 10.1007/BF02911613

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Pathological study of chronic lobular hepatitis— with special reference to pathology, diagnostic criteria, etiology and pathogenesis on the basis of analysis of 25 liver biopsies

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Abstract

25 liver biopsies of chronic lobular hepatitis (CLH) were studied with special reference to pathological characteristics, diagnostic criteria, etiology and pathogenesis. The pathological characteristics of CLH are similar to those of a mild variety of virus hepatitis, but the symptoms of CLH are usually mild and its course is longer than 6 months. The diagnosis can be made by the pathological changes and the course of the disease. This viewpoint is identical with that of foreign authors, 20 cases (80 %) in our series were found to be HBsAg positive by the double bridge PAP immunohistochemical method. Distribution of various patterns of antigen in the hepatocytes was seen, among which membranous typeI HBsAg was predominant (44%) and the cytoplasmic type ranked second (32 %). In 5 cases HBsAg was negative. The distributive patterns of membranous typeI HBsAg seem to reflect a mild immune injury of hepatic cells, a condition of low function of immunity, and residual viral antigen which could not be cleared away in time, and the patients revealed clinically mild symptoms and a longer course. The focal necrosis and the hepatic cells around it showed that the HBsAg decreased or even disappeared. This seems to explain that the patients possessed certain immune ability against the viral agent.

Keywords

chronic hepatitis / chronic lobular hepatitis / DPAP

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Wu Xiu-gan, Liu Shao-chun, Zhang Xiao-jing, Hu Zong-yi. Pathological study of chronic lobular hepatitis— with special reference to pathology, diagnostic criteria, etiology and pathogenesis on the basis of analysis of 25 liver biopsies. Current Medical Science, 1986, 6(1): 21-25 DOI:10.1007/BF02911613

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