Effects of fenvalerate on enzymes of rat liver cell membranes and microsomes

Abstract

By exploring the effects of fenvalerate on enzymes of rat liver cell membranes and microsomes, it was found that fenvalerate inhibited the activities of liver plasma membrane-bound 5′-Nase and ALP in different extent, induced microsomal AH activity and increased cytochrome P-450 content. A preliminary study was made to elucidate the possible mechanism of these effects.

Keywords

fenvalerate / enzymes of liver plasma membranes / 5′-nucleotidase / alkaline phosphatase / Na⁺ / K⁺-ATPase / Mg⁺⁺-ATPase / γ-glutamyltransferase / microsomal enzymes / cytochrome P-450 / aniline hydroxylase

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