Expression and clinical significance of p27kip1 protein in primary liver cancer

Abstract

To investigate the expression and clinical significance of p27kip1 protein in primary liver cancer, the expression of p27kip1 protein and the relationship with clinicopathological factors were studied in primary liver cancer by using SABC immunohistochemical staining in specimens of 40 cases of primary liver cancer and 20 cases of liver cirrihosis. Our results showed that positive expression rate of p27kip1 protein in primary liver cancer was 37.5% (15/40), which was lower than that in benign lesion of liver 80.0% (16/20,P<0.01). The expression level of p27kip1 protein in primary liver cancer showed significant differences in tumor size, Edmonson histological grade, portal invasion, lymph node metastasis, TNM stage (P<0.05, for all), but not significantly correlated with patients age and histological types. Log rank test showed that the p27kip1 expression was significantly related with prognosis of the patients (P<0.05), and the prognosis of the patients with p27kip1 positive expression was markedly better than that of those with p27kip1 negative expression. It is concluded that the expression of p27kip1 was significantly related clinicopathological factors of primary liver cancer, p27kip1 protein may be used as a novel tumor marker for primary liver cancer.

Keywords

liver neoplasm / carcinoma / p27kip1 protein / immunohistochemistry

References

[1] CraigJ R, PettersR L, EdmondsonL A. Tumors of the liver and intrahepatic bile ducts, 1989, Washington DC, Armed Forces Institute of Pathology: 123-123

[2] PiaparroneM, YamanotoH, YaY, et al. . Localization and expression of p27 in multistage. Cancer Res, 1998, 58: 114-114

[3] LioydR V, JinL, QianX, et al. . Aberrant p27kip1 expression in endocrine and other tumors. Am J Pathol, 1997, 150: 401-401

[4] JinL, QianX, KulingE, et al. . Transforming growth factor-beta, transforming growth factor-beta receptor Il, and p27kip1 expression in nontumorous and neoplastic human pituaries. Am J Pathol, 1997, 151: 509-509

[5] HuiA M, CuiX, MakuuchiM, et al. . Decreased p27 (kip1) expression and cyclin D1 overexpression, alone and in combination, influence recurrence and survival of patients with resectable extrahepatic bile duct carcinoma. Hepatology, 1999, 30(5): 1167-1167

[6] MinetaH, MiuraK, SuzukiiI, et al. . Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma. Cancer, 1999, 5: 1011-1011

[7] LodaM, CukorB, TanS W, et al. . Increased proteasome dependent degradation of the cyclin dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med, 1997, 3: 231-231

[8] TanP, CadyB, WannerM, et al. . The cycle inhibitor p27 is an independent prognostic marker in small invasive breast carcinomas. Cancer Res, 1997, 57: 1259-1259