Clinical measurement of antibodies against acetylcholine receptor (AchR), SOD and LPO in patients with myasthenia gravis (MG) before and after thymectomy

Abstract

The antibodies against acetylcholine receptor AchR and levels of SOD and LPO were measured in 11 patients with myasthenia gravis (MG), and the results were compared with normal controls and patients with diseases other than MG. The results showed that the antibodies against AchR were higher as compared with other groups before and after operation. The post-operative level of antibodies was obviously lower than the pre-operative value. An slight increase in SOD and significant decrease in mean value of LPO after surgery were noted. The possible mechanism was discussed.

Keywords

myasthenia gravis / antibodies / acetylcholine receptor / SOD / LPO

References

[1] PatrickJ, LindstromJ. Autoimmune response to acetylcholine. Science, 1973, 180: 871-871

[2] LindstromJ. Antibody to acetylcholine receptor in myasthenia gravis; prevalence, clinical correlated and diagnostic value. Neurol, 1976, 26: 1054-1054

[3] BuchinghamJ M, HowardFM, BernatPE, et al. . The value of thymectomy in myasthenia gravis: A computer-assisted matched study. Ann Surg, 1976, 184: 453-453

[4] BerrihS. Depletion of helper/inducer T cells after thymectomy in myasthenic patients. Clin Immunol Immunopath, 1983, 28: 272-272