Phenotype analysis of mononuclear cells in endomyocardial biopsy specimens from patients with viral myocarditis and dilated cardiomyopathy

Abstract

This study investigated the distribution and phenotype of mononuclear cells in endomyocardial biopsy (EMB) specimens from patients with viral myocarditis (VMC, 25 cases) and dilated cardiomyopathy (DCM, 10 cases). T lymphocytes, including T_h/i cells in VMC and T_c/s cells in DCM, predominated in the infiltrating mononuclear cells in these specimens. The morphological relationship between infiltration of T lymphocytes and pathological changes of myocardia was also observed and neither macrophages nor B lymphocytes were found.

Keywords

myocarditis / congestive cardiomyopathy / biopsy, myocardium / T lymphocyte

References

[1] KereiakesD J, ParmleyW W. Myocarditis and cardiomyopathy. Am Heart J, 1984, 108: 1319-1319

[2] DeguchiH, HayashiT, KotakaM, et al. . In situ analysis with monoclonal antibodies of lymphocyte subsets in myocardial biopsies from patients with dilated cardiomyopathy and idiopathic (viral) myocarditis. Jpn Circ J, 1987, 51: 1365-1365

[3] 1987, 26: 597.

[4] WHO/ISFC Task Force. Report of the WHO/ ISFC task force on the definition and classification. of cardiomyopathies. Br Heart J, 1980, 44: 672-672

[5] AretzH T, BillinghamM E, EdwardsW D, et al. . Myocarditis; a histopathologic definition and classification. Am J Cardiovasc Pathol, 1987, 1: 3-3

[6] 1986, 15: 282

[7] 1990. 69–70

[8] 1990, 7, 10

[9] 1991: 89–92

[10] 1989, 18: 79