Serum IL-10 level in allergic rhinitis patients and its effect on serum total IgE

Abstract

To investigate the level of serum IL-10 in allergic rhinitis patients and the correlation between IL-10 and serum total IgE (TIgE). 50 allergic rhinitis patients and 30 normal subjects were involved in the study. The levels of serum IL-10 and TIgE were measured by enzyme-linked immunosorbent assay (ELISA), and the correlation between serum IL-10 and TIgE was analyzed. In the allergic rhinitis group, the levels of serum IL-10 and TIgE were 8.34±2.48 pg/mL and 142.6±28.2 KU_Λ/L. In the normal control group, they were 12.86±2.88 pg/mL and 47.2±12.2 KU_Λ. There were significant differences between the two groups (P<0.01); and the level of serum TIgE in the patients was negatively correlated with that of IL-10 (r=−0.46,P=0.02). The level of serum IL-10 was significantly decreased in allergic rhinitis patients, which was beneficial to the synthesization of IgE. IL-10 plays an important role in the episode of allergic rhinitis.

Keywords

allergic rhinitis / IL-10 / total IgE

References

[1] LevingsM K. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol, 2002, 129: 263-263

[2] WuY J, ChenR H. IL-10 downregulates expression of cyclo-oxygenase-2 and its mediated PGE2 production on human mesangial cells. Immunol J, 2001, 17: 421-421

[3] Otorhinolaryngology Branch of China Medical Association. Diagnosis Criterion of Allergic Rhinitis (revised, Haikou, 1997). Chin J Otorhinolaryngol, 1998, 33: 134-134

[4] BousquetJ, Van CauwenbergeP, KhaltaevN. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol, 2001, 108(Suppl 5): 147-147

[5] AbdelnoorA M, KobeissyF, FarhatD, et al. . Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon. Clin Mol Allergy, 2004, 2(1): 6-6

[6] NgocL P, GoldD R, TzianabosA O, et al. . Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol, 2005, 5(2): 161-161

[7] FernandoR, ChanR. Anti-inflammatory pre-treatment and the resultant effects of interleukin-10: adjuncts to multi-therapeutical strategies. Perfusion, 2000, 15: 501-501