Assessment of left ventricular longitudinal regional myocardial systolic function by strain imaging echocardiography in patients with hypertrophic cardiomyopathy

Abstract

To assess the left ventricular longitudinal regional myocardial systolic function by strain imaging (SI) echocardiography and to study the relationship between regional myocardial systolic function and left ventricular structure in patients with hypertrophic cardiomyopathy (HCM). SI echocardiography were performed in 18 patients with HCM and 17 healthy subjects. For each wall, regional myocardial systolic strain was analyzed at the basal, mid, and apical level respectively. And the peak systolic strain was measured. Our results showed that the patients with HCM had reduced peak systolic strain at almost each segment of different walls when compared with healthy subjects. There was significant correlation between the mid-septum peak systolic strain and the thickness of IVS, so was the correlation between the mid-septum peak systolic strain and the IVS to LVPW thickness ratio. This study demonstrated that the left ventricular longitudinal regional myocardial systolic function was abnormal in HCM, and this kind of abnormalities existed extensively in hypertrophic and non-hypertrophic cardiac segments. The degrees of left ventricle hypertrophy and asymmetry are related to the myocardial regional systolic function in HCM.

Keywords

echocardiography / strain imaging / cardiomyopathy / hypertrophic / ventricular function

References

[1] FananapazirL. Advances in molecular genetics and management of hypertrophic cardiomyopathy. JAMA (Chinese edition), 2000, 19(2): 73-73

[2] CristinaP, TheodoreP A, MarekB, et al. . Strain and strain echocardiography. Curr Opin Cardiol, 2002, 17: 443-443

[3] UrheimS, EdvardsenT, TorpH, et al. . Myocardial strain by Doppler echocardiography validation of a new method to quantify regional myocardial function. Circulation, 2000, 102(10): 1158-1158

[4] KarlonW J, CovellJ W, McCullochA D, et al. . Automated measurement of myofiber disarry in transgenic mice with ventricular expression of ras. Anat Rec, 1998, 252(4): 612-612

[5] MarianA J. Pathogenesis of diverse clinical and pathological phenotypes in hypertropihc cardiomyopathy. Lancet, 2000, 355(9197): 58-58

[6] NaguehS F, KopelenH A, LimD S, et al. . Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation, 2000, 102(12): 1346-1346

[7] LiuY N, DengY B, LiX L, et al. . Assessment of The Regional Left Ventricular Systolic Function by Myocardial Velocity Gradient in Patients with Hypertrophic Cardiomyopathy. Chin J Med Imaging Technol, 2004, 130(3): 411-411