Immune vasculitis induced atherosclerosis

Abstract

The relationship between immune vasculitis and atherosclerosis was studied. The experimental model of weanling rabbits for immune vasculitis was reproduced by intravenous injection of 10% bovine serum albumin. There were 6 groups: group A, 25 weanling rabbits with immune vasculitis subject to coronary arteriography; group B, 10 normal mature rabbits subject to coronary arteriography; group C, 10 weanling rabbits subject to coronary arteriography; group D, 8 weanling rabbits with vasculitis and cholesterol diet; group E, 8 weanling rabbits receiving single cholesterol diet; group F: 8 weanling rabbits receiving basic diet. Four weeks later, coronary arteriography was performed in groups A, B and C. The rabbits in groups D, E and F were sacrificed for the study of pathological changes in the coronary artery after 12 weeks. The results showed that the dilatation of coronary artery occurred in 6 rabbits of group A, but in groups B and C, no dilatation of coronary artery appeared. In comparison with group E, more severe atherosclerosis occurred in group D, showing the thickened plaque, fibrous sclerosis and atherosclerotic lesion. Percentage of plaques covering aortic intima, incidence of atherosclerosis of small coronary arteries and degree of stenosis of coronary arteries were significantly higher in group D than in group E, (P<0.01). No atherosclerosis changes were found in group F. It was concluded that in the acute phase, the serum immune vasculitis can induce the dilatation of coronary artery of some weanling rabbits, and aggravate the formation of atherosclerosis in rabbits fed with cholesterol diet. Immune vasculitis is a new risk factor of atherosclerosis and ischemic heart disease.

Keywords

immune vasculitis / atherosclerosis / ischemic heart disease / risk factor

References

[1] OnouchiZ, IkutaK, NagamatsuK, et al. . Coronary artery aneurysms develop in weanling rabbits with serum sickness but not in mature rabbits. An experimental model for Kawasaki disease in humans. Angiology, 1995, 46(8): 679-679

[2] BurnsJ C, KushnerH I, BastianJ F, et al. . Kawasaki disease: A brief history. Pediatrics, 2000, 106(2): E27-E27

[3] RossR. Atherosclerosis-an inflammatory disease. N Engl J Med, 1999, 40(2): 115-115

[4] VanD S, McCollG, WicksI P. Accelerated atherosclerosis: an extraarticular feature of rheumatoid arthritis?. Arthritis Rheum, 2002, 46(4): 862-862

[5] DaneshJ, CollinsR, PetoR. Chronic infections and coronary heart disease: is there a link?. Lancet, 1997, 350: 430-430