Effect of non-specific HCN₁ blocker CsCl on spatial learning and memory in mouse

Abstract

It has been suggested that HCN₁ is primarily expressed in hippocampus, however little is known about its effects on spatial learning and memory. In the present study, we investigated the effects of non-specific HCN₁ blocker CsCl on spatial learning and memory by using Morris water maze andin situ hybridization in mice. The results showed CsCl 160 mg/kg ip for 4 days, and the mean escape latency was 34 s longer than that of normal control (P<0.01). In hippocampal tissues, staining for the HCN₁ mRNA was stronger in the DG and CA1 region of the hippocampus (P <0.05,P<0.05, when CsCl-administration group was compared with normal group). Our results suggested that CsCl could significantly affect the spatial learning and memory in mice, and HCN channel is involved in the process of learning and memory.

Keywords

CsCl / HCN channel / behavior / mice

References

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