Effect of different drugs on end-tidal carbon dioxide during rodent CPR

Abstract

The purpose of this study was to investigate the effect of non-adrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO₂(ETCO₂) during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasoprestn (AVP) and angiotension-I (ANG-II), but not by endothelin-1 (ET-l); 2) ETCO₂ prior to defibrillation was decreased significantly by a pure α₁ adrenergic agents, methoxamine and were increased significantly by non-adrenergic agents, ANG-I and ET-l during rodent CPR: 3) a significant positive correlation between ETCO₂ and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-II have similar effect on resuscitability during rodent CPR.

Keywords

cardiopulmonary resuscitation / coronary perfusion pressure / end-tidal carbon dioxide / methoxamine / arginine vasopressin, angiotensin-II, endothelin-1

References

[1] TrilloG, von PlantaM, KetteF. ETCO₂ monitoring during low flow states: clinical aims and limits. Resuscitation, 1994, 27: 1-1

[2] von PlantaI, WeilM H, von PlantM. Cardiopulmonary resuscitation in the rat. J Appl Physiol, 1988, 65: 2641-2641

[3] SandersA B, AtlasM, EwyGA, et al. . Expired PCO₂ as an index of coronary perfusion pressure. Am J Emerg Med, 1985, 3: 147-147

[4] TangW, WeilM H, GazmuriR J, et al. . Pulmonary ventilation/perfusion defects induced by epinephrine during cardiopulmonary resuscitation. Circulation, 1991, 84: 2101-2101

[5] von PlantaM, GudipatiC V, WeilM H, et al. . Effects of tromethamine and sodium bicarbonate buffers during cardiac resuscitation. J Clin Pharmacol, 1988, 28: 594-594

[6] von PlantaI, WagnerO, von PlantaM, et al. . Coronary perfusion pressure endtidal CO₂ and adrenergic agents in haemodynamic stable rats. Resuscitation, 1993, 25: 203-203