Effect of different drugs on end-tidal carbon dioxide during rodent CPR

Abstract

The purpose of this study was to investigate the effect of non-adrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO₂(ETCO₂) during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasoprestn (AVP) and angiotension-I (ANG-II), but not by endothelin-1 (ET-l); 2) ETCO₂ prior to defibrillation was decreased significantly by a pure α₁ adrenergic agents, methoxamine and were increased significantly by non-adrenergic agents, ANG-I and ET-l during rodent CPR: 3) a significant positive correlation between ETCO₂ and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-II have similar effect on resuscitability during rodent CPR.

Keywords

cardiopulmonary resuscitation / coronary perfusion pressure / end-tidal carbon dioxide / methoxamine / arginine vasopressin, angiotensin-II, endothelin-1