Immunohistochemical analysis of EGF-R in gastric mucosa in portal hypertensive with cirrhosis

Abstract

PAP Immunohistochemical technique was used to detect the expression and distribution of EGF-R in gastric mucosa in portal hypertensive pigs with cirrhosis. Our result showed that the EGF-R content in gastric mucosa of portal hypertensive pigs was significantly lower than that in control group. Microscopically, the portal hypertension (PHT) group imparted “feeble positivity ” or “negative results ” and the control group showed “strong positivity ”. It was suggested that the decrease of EGF-R content in gastric mucosa weakened defense mechanism of gastric mucosa and increase its vulnerability. It is believed that the decreased EGF-R in gastric mucosa is ascribed to the lesions of gastric mucosa during PHT with cirrhosis.

Keywords

cirrhosis / portal hypertension / gastric mucosa / EGF-R / PAP, immunohistochemistry