Study on relationship between anticardiolipin antibody and cerebrovascular diseases

Abstract

Serum anticardiolipin antibody (ACA) was measured in 91 patients with cerebral infarction (CI), 42 patients with cerebral hemorrhage (CH) and 30 healthy controls. The results showed that the ACA in CI and CH patients was significantly higher than in controls and IgG-ACA was the most important iso-type. Stroke in ACA positive group tended to be recurrent and of multi-focuses. Positive rate of IgG-ACA reached its peak within the first week after stroke on-set. The results suggested that ACA was an independent risk factor in CI and CH and might be valuable in stroke prediction.

Keywords

anticardiolipin antibody / cerebral infarction / cerebral hemorrhage

References

[1] MontalbanJ, RioJ, KhamasthaM, et al. . Value of immunologic testing in stroke patients. A prospective multicentre study. Stroke, 1994, 25: 2412-2412

[2] ENA 1997, 10:18

[3] 1997, 5:331

[4] BreyR L, CoullB M. Antiphospholipid antibodies: origin, specificity and mechanism of action. Stroke, 1992, 23(Suppl 115-15

[5] LevineS R, BreyR L, SawayaK L, et al. . Recurrent stroke and thrombo-occlusive event in the antiphospholipid syndrome. Ann Neurol, 1995, 38: 119-119

[6] ProvenzaleJ M, BarboriakD P, AllenN B, et al. . Patients with antiphospholipid antibodies: CT and MR findings of the brain. AJR, 1996, 167: 1573-1573

[7] MuirK W, SquireI B, AlwanW, et al. . ACA in an unselected stroke population. Lancet, 1994, 344: 452-452

[8] KushnerM J. Prospective study of anticardiolipin antibodies in stroke. Stroke, 1990, 21: 295-295

[9] APASS Group. Anticardiolipin antibodies are independent risk factor for first ischemic stroke. Neurology, 1993, 43: 2069-2069

[10] CamerlingoM, CastoL, CensoriB, et al. . Anticardiolipin antibodies in acute nonhemorrhagic stroke seen within six hours after stroke onset. Acta Neurol Scand, 1995, 92: 69-69