C-Ha-ras oncogene in oral leukoplakia tissues

Abstract

The amplification and the G-T mutation at codon l2 of the C-Ha-ras oncogene in oral leukoplakia tissues were analyzed by using polymerase chain reaction (PCR) and molecular biologic technique. The results showed that these tissues had no amplification of Ha-ras oncogene. Only one case harbored G-T mutation in 11 oral leukoplakias, but this mutation was absent in 10 normal oral mucosal tissues. The possible role and significance of C-Ha-ras oncogene in oral precancerous lesions were also discussed.

Keywords

oral leukoplakia / ras oncogene / mutation / amplification

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