Glioma prostaglandin levels correlate with brain edema

Abstract

The present study was designed to prospectively investigated the prostaglandin (PG) levels and extent of peritumoral edema in 30 cases of glioma by using methods of radioimmunoassay and imaging. Both TXB₂ and 6-keto-PGF₁₀ levels in all glioma groups went up over that in the control group. TXB₂ level and ratio of TXB₂/6-keto-PGF₁₀ were markedly increased with the extent of tumor malignancy. Water concentration in anaplastic astrocytoma and glioblastoma were significantly elevated. Difference in TXB₂ level and TXB₂/6-keto-PGF₁₀ ratio among three edema grades were statistically significant. TXB₂ level and ratio of TXB₂/6-keto-PGF₁₀ were closely correlated with water concentration (r₁ = 0. 53, r₂ = 0. 72,P <0. 01). Our findings suggested that the metabolism of PG in glioma were in the state of disorder, and that the imbalance between PGI₂ and TXA₂ may be one of factors which affect the formation of peritumoral edema.

Keywords

glioma / brain edema / prostaglandins