Glioma prostaglandin levels correlate with brain edema

Abstract

The present study was designed to prospectively investigated the prostaglandin (PG) levels and extent of peritumoral edema in 30 cases of glioma by using methods of radioimmunoassay and imaging. Both TXB₂ and 6-keto-PGF₁₀ levels in all glioma groups went up over that in the control group. TXB₂ level and ratio of TXB₂/6-keto-PGF₁₀ were markedly increased with the extent of tumor malignancy. Water concentration in anaplastic astrocytoma and glioblastoma were significantly elevated. Difference in TXB₂ level and TXB₂/6-keto-PGF₁₀ ratio among three edema grades were statistically significant. TXB₂ level and ratio of TXB₂/6-keto-PGF₁₀ were closely correlated with water concentration (r₁ = 0. 53, r₂ = 0. 72,P <0. 01). Our findings suggested that the metabolism of PG in glioma were in the state of disorder, and that the imbalance between PGI₂ and TXA₂ may be one of factors which affect the formation of peritumoral edema.

Keywords

glioma / brain edema / prostaglandins

References

[1] WahlM, UpterbergA, BaethmannA, et al. . Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema. J Cereb Blood Flow Metab, 1988, 8: 621-621

[2] GreenwoodJ. Mechanisms of blood-brain barrier breakdown. Neurosurgery, 1991, 33: 95-95

[3] CooperC, JonesH G, WellerR O, et al. . Production of prostaglandins and thromboxane by isolated cells from intracranial tumors. J Neurol Neurosurg Psychiatry, 1984, 47: 579-579

[4] CastelliM G, ButtiG, ChiabrandoC, et al. . Arachidonic acid metabolic profiles in human meningiomas and gliomas. J Neuro-Oncol, 1987, 5: 369-369

[5] GaetaniP, BaenaR R, MarzaticoF, et al. . Ex vivo” release of eicosanoid from human brain tissue: its relevance in the development of brain edema. Neurosurgery, 1991, 28: 853-853

[6] ConstantiniS, TamirJ, GomoriM J, et al. . Tumor prostaglandin levels correlate with edema around supratentorial meningiomas. Neurosurgery, 1993, 33: 204-204

[7] OkadaY, KloberO, HossmannK A. Regional metabolism in experimental brain tumor in cats, relationship with acid/base, water, and electrolyte homeostasis. J Neurosurg, 1992, 77: 917-917