Action of DDPH in the intervential treatment of portal hypertension induced by liver cirrhosis in rabbits

Abstract

To explore a new way of utilizing intervential treatment to effectively decrease the portal hypertension, the animal models of liver cirrhosis accompanying portal hypertension were set up by intraportal vein injection of suspensions of Bletilla striata to10 rabbits by means of prospective investigational method. The catheter filled with heparin solution was remained in theportal vein for infusion of drugs. Three weeks later, DDPH solution was injected into the portal vein via the catheter to determine its effect of decreasing portal vein pressure and its influence of peripheral blood pressure and heart rate. At the same time, other10 rabbits with liver cirrhosis associated with portal hypertension were subjected to the injection of DDPH solution via the ear vein served as control group. The results showed that administration of DDPH by portal vein could rapidly, safely and effectively decrease the portal hypertenive pressure without side effects and partially reverse liver cirrhosis, as compared with injection of DDPH via peripheral veins. It was concluded that DDPH exerted its α₁-adrenoceptor blocking and calcium antagonistic effects, thereby significantly reduce the portal hypertension. Injection of DDPH via portal vein is a completely new and relaible method for the treatment of liver cirrhosis with portal hypertension.

References

[1] FengX S, QiuF Z, XuZ. Experimentelle Embolisation unterschiedlicher hepatischer Gefaesse beim Hund mit Bletilla striata. J Tongji Med Uni, 1994, 15: 48-48

[2] FengG S, KramannB, ZhengC S, et al. . Permanent Chemoembolisation des Leberkarzinoms mit dem chinesischen Heilmittel Bletilla striata: Langzeitergebnisse im Vergleich mit Lipidol-MMC-Gelfoam. J Tongji Med Uni, 1996, 16: 115-115

[3] SieberC C, StalderG A. Pathophysiologische und pharmakotherapeutische Aspekte der portalen Hypertonie. Schweiz Med Wschr, 1993, 123: 3-3