Effect of low HDL combined with hypertriglyceridemia in coronary artery disease patients on PGI2 biological activity in relation to lipid regulating treatment

Li Jingdong; Dai Guizhu; Feng Zongchen; Wang Cunben; Yang Yan; Wei Wenning; Zhou Bencai

doi:10.1007/BF02888473

Current Medical Science ›› 1998, Vol. 18 ›› Issue (2) : 87 -89. DOI: 10.1007/BF02888473

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Effect of low HDL combined with hypertriglyceridemia in coronary artery disease patients on PGI₂ biological activity in relation to lipid regulating treatment

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Abstract

The purpose of this study was to investigate the effect of low high-density-lipoprotein (HDL) combined with hypertriglyceridemia in coronary artery disease (CAD) patients on prostaglandin I₂(PGI₂) biological activity in relation to lipid regulating treatment. The inhibitory rate of PGI₂ on ADP-induced platelet aggregation was used as the index for PGI₂ biological activity. Twenty health individuals served as normal controls. CAD group consisted of 20 patients with low HDL combined with hypertriglyceridemia. The results showed that, before the treatment, the stabilizing effect on PGI₂ activity decreased significantly in CAD group when compared with the control group (P <0.01). One month after the treatment, HDL level in CAD group increased significantly and TG level significantly decreased (P <0.001). The different effect on PGI₂ activity was no longer found between CAD group and control group (P > 0. 05), further confirming the protecting effect of HDL on PGI₂ biological activity. Low HDL is considered as an important risk factor of CAD, therefore, impaired PGI₂ biological activity and increased platelet aggregation might be responsible mechanisms. Furthermore, raising HDL level by lipid regulating treatment could restore the protective effect of HDL on PGI₂ and might be helpful in the prevention of the acute coronary syndrome.

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high-density-lipoprotein / hypertriglyceridemia prostaglandin I₂ / coronary artery disease

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Li Jingdong, Dai Guizhu, Feng Zongchen, Wang Cunben, Yang Yan, Wei Wenning, Zhou Bencai. Effect of low HDL combined with hypertriglyceridemia in coronary artery disease patients on PGI₂ biological activity in relation to lipid regulating treatment. Current Medical Science, 1998, 18(2): 87-89 DOI:10.1007/BF02888473

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