Effects of huangdan capsule on plasma cGMP and ANP in rats with chronic renal failure

Zheng Jianfeng, Hong Shuyun, Chen Siyuan, Chen Jingchun, Zhang Changgong

Current Medical Science ›› 1998, Vol. 18 ›› Issue (2) : 75-77.

Current Medical Science ›› 1998, Vol. 18 ›› Issue (2) : 75-77. DOI: 10.1007/BF02888470
Article

Effects of huangdan capsule on plasma cGMP and ANP in rats with chronic renal failure

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Abstract

The model of chronic renal failure (CRF) was made in 5/6 nephrectomized rats and Huangdan capsule was used to treat these rats. The levels of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) in plasma were examined. The results showed that Huangdan capsule could postpone the increase in the levels of cGMP and ANP, suggesting that by regulating the water and sodium metabolism, Huangdan capsule could ameliorate the glomerular filtration rate, and that Huangdan capsule could lower the levels of cGMP and ANP in plasma via body regulation.

Keywords

Huangdan capsules / chronic renal failure / cyclic guanosine monophosphate / atrial natriuretic peptide

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Zheng Jianfeng, Hong Shuyun, Chen Siyuan, Chen Jingchun, Zhang Changgong. Effects of huangdan capsule on plasma cGMP and ANP in rats with chronic renal failure. Current Medical Science, 1998, 18(2): 75‒77 https://doi.org/10.1007/BF02888470

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