The interaction between endogenous opioid peptides and GABA in lower brain stem

Abstract

The interaction between endogenous opioid peptides and GABA in lower brain stem in cardiovascular regulation was investigated. The results of our experiments suggested that endogenous opioid peptides and GABA in lower brain stem can reinforce each other in their inhibitory effect on blood pressure, but the mechanism of the interaction remains to be elucidated.

Keywords

cardiovascular regulation / sympathetic nerve discharges / endogenous opioid peptides / endogenous GABA

References

[1] AtewehS F, KuharMS. Autoradiografic localisation of opiate receptor in rat brain. Brain Res, 1977, 129: 1-12

[2] EldeR, et al. . HugherJ, et al. . Immunohistochemical localisation of peptides in the nervous system. Centrally Acting Peptides, 1978, London, Macmillian: 17-35

[3] UhlGR, et al. . Immunohistochemical mapping of enkephalin containing cell body, fibres and nerve terminals in the brain stem of the rat. Brain Res, 1979, 167: 77-91

[4] DietrichWD, et al. . The distribution of glutamate, GABA and aspartate in the nucleus tractus solitarii of the cat. Brain Res, 1982, 237: 254-60

[5] HwangBH, et al. . Ultrastructural studies on catecholaminergic terminals and GABAergic neurons in nucleus tractus solitarii of the rat medulla oblongata. Brain Res, 1984, 302: 57-67

[6] AroninH, et al. . Localisation of immunoreaction enkephalins in GABA synthesizing neurons of the rat neostratium. Brain Res, 1984, 300: 376-80

[7] FryJP, et al. . Comparison of the effects of GABA and enkephalin on synaptically evoked activity in the rat striatum. Appl Neurophysiol, 1979, 42: 54-6

[8] Chan-palayV, et al. . Inhibitory effects of motilin, somatostatin, Leu-enkephalin, Met-enkephalin and taurine on neurons of the lateral vestibular nucleus: interaction with γ-aminobutyric acid. Proc Nat Acad Sci USA, 1982, 79: 3355-9

[9] YonedaY. Possible involvement of GABA in morphine analgesia. Biochem Pharmacol, 1976, 25: 2669-70

[10] DhumalVR, et al. . Central hypotensive effects of γ-aminobutyric acid in anaesthetized dogs. J Pharm Pharmacol, 1980, 32: 724-5

[11] AntonaccioMJ, et al. . Reduction in blood pressure, heart rate and renal sympathetic nerve discharge after imidazole-4-acetic acid: mediation through central γ-aminobutyric acid (GABA) receptor stimulation. J Pharmacol Exp Ther, 1981, 218: 200-5

[12] WillifordDJ, et al. . Central nervous system mechanisms involving GABA influence arterial pressure and heart rate in the cat. Circ Res, 1980, 47: 80-8

[13] FreyeE, et al. . Perfusion of the fourth cerebral ventricle with fentanyl induces naloxone-reversible bradycardia, hypotensive and EEG synchronisation in conscious dogs. Naunyn-Schmiedebergs Arch Pharmacol, 1979, 307: 123-8