Cardiovascular aspects of pharmacology of berberine: I. α-adrenoceptor blocking action of berberine in isolated rat anococcygeus muscle and rabbit aortic strip

Abstract

The cumulative dose-response curves for phenylephrine were shifted parallelly to the right by berberine and prazosin without any change in the maximal response. The pA₂ values of berberine in the isolated rat anococcygeus muscle and rabbit aortic strip were 6.62 and 6.54 respectively. The results indicate that berberine, like prazosin, has a competitive α-adrenoceptor blocking action.

Keywords

berberine / prazosin / phenylephrine / adrenergic alpha receptor blocker / anococcygeus muscle / aorta / drug dose-response relationship

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