Clinical study on chronopharmacokinetics of digoxin in patients with congestive heart failure

Abstract

Fluorescence polarization immunoassay was used to study the chronopharmacokinetics of digoxin in 10 patients with congestive heart failure (CHF) who also served as self-controls. Our results showed that the serum digoxin concentration reached peak value 1 h after taking digoxin at 7:00 a.m., but the serum digoxin concentration reached the peak value 2 h after taking digoxin at 4:00 p.m.. The average serum digoxin concentration area under curve was greater and the best maintainable time of serum concentration within 24 h after taking digoxin at 4 p. m. longer than those at 7:00 a.m.. The heart rates were obviously lower and the cardiac function was significantly improved in 4:00 p.m. group.

Keywords

digoxin / congestive heart failure / chronopharmacokinetics

References

[1] MahdyoonH, BattilanaG, RosmanH, et al.. The evolving pattern of Digoxin intoxication: observations at a large urban hospital from 1980 to 1988. Am Heart J, 1990, 120(5): 1189-1189

[2] KopeckaJ. Chronopharmacokinetics of digoxin in compensated cardiac patients. Vnitr Lek, 1992, 38(6): 566-566