Lipids, lipoproteins and apolipoproteins abnormalities in patients undergoing dialysis

Abstract

Twenty hemodialysis (HD) patients and 20 patients on continuous am bulatory peritoneal dialysis (CAPD) were investigated for lipids, lipoproteins and apolipoproteins abnormalities. HD patients had elevated serum triglyceride, decreased high-density hpoprotein cholesterol (HDL-C) and apohpoprotein A-I (Apo A-I), while CAPD patients had elevated total cholesterol, triglyceride, low-density hpoprotein cholesterol (LDL-C), Apohpoprotein B (Apo B), Apo B/ Apo A-Iratio, and decreased HDL-C, Apo A-I. Because of the molecular sieving effects of peritoneum, CAPD have a negative effect on these abnormalities. CAPD patients might be at greater risk of developing coronary artery disease than HD patients who are also at increased riskas compared with normals.

Keywords

hpoprotein / apohpoprotein / dialysis

References

[1] AppelG. Lipid abnormalities in renal disease. Kidney Int, 1991, 39: 169-169

[2] AttmanP O, AlaupovicP. Lipid and apolipoprotein profiles of uremic dyslipoproteinemic—Relation to renal function and dialysis. Nephron, 1991, 57: 402-402

[3] BonominiV, FelettiC, ScolariM P, et al.. Atherosclerosis in uremia: A longitudinal study. Am J Clin Nutr, 1980, 33: 1493-1493

[4] MaiorcaR, CancariniG C, BrunoriG, et al.. Morbidity and mortality of CAPD and hemodialysis. Kidney Int, 1993, 43(suppl 40): s4-s4

[5] WuG. the University of Toronto Collaborative Dialysis Group. Cardiovascular deaths among CAPD patients. Perit Diall Bull, 1983, 3(suppl 3): s23-s23

[6] SnidermanA, CianfloneK, KwiterovichP O, et al.. Hyperapobetalipoproteinemia: the major dyslipoproteinemia in patientswith chronic failure treated with chronic ambulatory peritoneal dialysis. Athrosclerosis, 1987, 65: 257-257

[7] NolphK D, LinabladA S, NovakJ W. Continuous ambulatory peritonealdialysis. N Engl J Med, 1987, 318: 1595-1595

[8] HorkkoS, HuttunenK, AnteroK Y. Decreased clearance of LDL inuremic patients under dialysis treatment. Kidney Int, 1995, 47: 1732-1732

[9] ShapiroR J. Catabolism of LDL is altered in ex perimental chronicrenal failure. Metabolism, 1993, 42: 162-162

[10] JankovaT, MitasJ A, WanenD J, et al.. Low prekallikrein and highangiotension converting enzyme activity in patients with chronic renalfailure on hemodialysis. Nephrol Dial Transplant, 1991, 6(suppl 3): 6-6