A model of subarachnoid cavity drugs perfusion and its clinical application in treatment of spinal cord injury

Abstract

An animal model of subarachnoid cavity drugs perfusion and its prehmllary clinical application in treatment of acute spinal cord injury (SCI) were reported. Analysis of the heart rate(HR), ECG, blood pressure (CVP, CAP), cerebrospinal fluid (CSF) pressuer and CSF gas and pH values of 10 healthy adult goats during subarachnoid daxamethasone, verapamd perfusion showed that this model was safe and reliable 26 patients with acute SCI were selected for a clinical obseration. Good results were obtained in 7 cases who received this treatment of subarachnoid cavity perfusion with dexamethasone and verapamil.

Keywords

subarachnoid cavity / drug perfusion / spinal cord injury (SCI)

References

[1] FrankelH L, HancockD O, HyslopG, et al.. The value postural reduction in the initial management of closed injury to the spine with paraplegia. Paraplegia, 1969, 7: 179-179

[2] American Spinal Injury Asscciation. Standards for neurological classfication of spinal injury patients, 1984ChicagoAmerican Spinal Injury Association115-200

[3] JanssenL, HanseboutR R. Pathogenesis of spinal cord injury and newer treatment. A review. Spine, 1989, 11(1): 23-23

[4] BrackenM B, SnepardM J, CollinsW F, et al.. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. N Engl J Med, 1990, 322(17): 1459-1459

This project was supported by the National Natural Science Foundation of China (No. 39270666).