Studies on the calcium antagonistic action of tetrandrine: XIV. Influence of tetrandrine and verapamil on hemodynamic action of ouabain in guinea pig

Abstract

After pretreatment with verapamil (Ver) and tetrandrine (Tet), the amount of ouabain required to induce the onset and peaking of inotropic effect as well as toxic reaction was increased, while peak value of positive inotropic effect was unaltered.

Neither the toxicity of ouabain nor its margin of safety was changed, but preventive and therapeutic action of Tet and Ver on ouabain-induced arrhythmia were demonstrated.

The anti-arrhythmic effects of tetrandrine, like Ver, may be relevant to Ca-antagonistic action.

Keywords

tetrandrine / verapamil / ouabain / hemodynamic / myocardial contraction

References

[1] FangDC, JiangMX. Studies on tetrandrine calcium antagonistic action. Chinese Medical J., 1986, 99(8): 638-44

[2] 1982;3(3):175–8.

[3] 1982;17(1):8–11.

[4] BahrmannH, GreeffK.. GreeffK. Evaluation of cardiac glycosides in the intact animal. Cardiac glycosides. Part 1. Experimental pharmacology, 19811st edBerlinSpringer117-52

[5] NaylerWG. Poole-Wilson Ph. Calcium antagonists: definition and mode of action. Basic Res Cardiol, 1981, 76: 1-1

[6] AntmamEM, et al.. Calcium channel blocking agents in the treatment of cardiovascular disorders, Part 1: Basic and clinical electrophysiologic effects. Ann Intern Med, 1980, 93(6): 875-85

[7] KleinHO, KaplinskyE. Verapamil and Digoxin: Their respective effects on atrial fibrillation and their interaction. Am J Cardiol, 1982, 50: 894-894

[8] 1983;4:258.