Effects of Anti-inflammatory Agent No.6 for injection on the oxidative burst of rat peritoneal macrophages

Abstract

Anti-inflammatory Agent No.6 for injection (AI-6) is an effective anti-infective agent composed of four traditional Chinese medicinal herbs. It was demonstrated in our experiment that the agent was able to enhance oxidative burst of rat peritoneal macrophages as shown by the increased production of H₂O₂ and increased reduction of nitroblue tetrazolium (NBT). It seems likely that by these means AI-6 could promote the bactericidal function of macrophages. NBT reduction of macrophages was observed by both spectrophotometric quantification and electron microscopy.

Keywords

macrophage / traditional Chinese medicines / NBT reduction / H₂O₂ release / ultrastructure

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