Changes in the level of IL-2, T cell subsets and the function of T suppressor cells in patients with schistosomiasis japonica

Abstract

The level of interleukin-2 (IL-2) produced by peripheral blood mononuclear cells in vitro, T cell subsets and the function of T suppressor cells (Ts) in patients with schistosomiasis japonica were investigated. It was found that the level of IL-2 induced by schistosomal antigens was significantly high and positively related to the percentage of CD4⁺ cells. In the groups of chronic and advanced schistosomiasis japonica, the level of IL-2 induced by schistosomal antigens was markedly lower than that in the group of acute schistosomiasis japonica, but significantly higher than that in the group of normal controls. The IL-2 level was negatively related to the percentage of CD8⁺ T cells and the ratio of CD4⁺/CD8⁺. The level of IL-2 induced by PHA was greatly reduced in the group of advanced schistosomiasis japonica. The changes in the level of IL-2 and its relationship with T cell subsets and the function of Ts are also discussed.

Keywords

schistosomiasis japonica / interleukin-2 / T cell subsets / T suppressor cell / immunoregulation

References

[1] StavitskyAB, et al.. Deficiency of interleukin-2 activity upon addition of soluble egg antigen to cultures of spleen cells from mice infected with schistosoma japonicum. Infect Immun, 1988, 56: 1778-1778

[2] StavitskyAB, et al.. Deficiency of interleukin-2 production upon addition of soluble egg antigen to cultures of isolated hepatic granulomas or hepatic granuloma cells from mice infected with schistosoma japonicum. Infect Immun, 1989, 57: 2339-2339

[3] SwingenbergerK, et al.. Release of interleukin 2 and gamma interferon by peripheral mononuclear cells in human schistosoma mansoni infection normalizes after chemotherapy. Scan J Immunol, 1989, 30: 463-463

[4] LiZJ, et al.. Changes in T cell subsets and T suppressor cell function and their relationship in human schistosomiasis japonica. J Tongji Med Univ, 1991, 11: 135-135

[5] GillisS, et al.. T cell growth factor parameters of production and a quantitative microassay for activity. J Immunol, 1978, 120: 2027-2027

[6] LewertRM, et al.. Lymphocyte responsiveness to phytohaemagglutinin and to worm and egg antigens in human schistosomiasis japonica. Am J Trop Med Hyg, 1979, 28: 92-92

[7] GazzinelliG, et al.. Immune response during human schistosomiasis mansoni. XI. Immunological status of patients with acute sch istosoma infection and after treatment. J Immunol, 1985, 135: 2121-2121

[8] GillisS, et al.. Molecular characterization of interleukin 2. Immunol Rev, 1982, 63: 167-167

[9] GattringerC, et al.. Spontaneous and Con A-induced suppressor lymphocytes: a comparative study. Immunobiology, 1981, 159: 293-293