Prognostic significance of CFU-GM and karyotype study in 103 cases of untreated nonlymphocytic leukemia

Abstract

The colony formation unit of granulo-monocytic progenitor cell (CFU-GM) growth pattern in the form of small clusters in 103 cases of untreated ANLL indicated favourable prognosis. These cases showed higher rate of complete remission, lower mortality rate and longer survival time than those with other three forms of growth patterns. Serial observations on the variations in number of CFU-GM colonies and in ratio of colonies to clusters are helpful in predicting the prognosis of leukemia. It was found that remission rate was not related to karyotype. However, the mortality rate in the patient group with normal karyotype was low, and the survival time was evidently prolonged. Serial studies of abnormal karyotypes can also help to predict the outcome of leukemia and to prove whether remission is achieved. Therefore, the combined study of CFU-GM and karyotype can provide early objective criteria which are more reliable than clinical parameters alone.

Keywords

acute nonlymphocytic leukemia / colony formation unit of granulomonocytic progenitor cell (CFU-GM) / karyotype

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