Experimental and clinical pancreas transplantation

Abstract

In the present, study two methods, duct-obliterated or duct-open with free drainage into the peritoneal cavity, have been used to tackle the problems of pancreatic exocrine drainage in pancreas auto- and allotransplantation in canine. Also, we have performed combined kidney and pancreas grafting in dogs.

On the basis of animal experiments, we have performed 3 duct-obliterated cadaveric segmental pancreas graftings in 3 patients who had insulindependent diabetes. One of them had functioning graft and became insulinindependent for more than one year. Motor nerve conduction velocity returned to normal 4 months after grafting. Signs of autonomous neuropathy, such as burning and numb sensations and chronic diabetes diarrhoea, subsided. From this study it becomes apparent that when rejection occurs, anti-coagulants and thrombolytic agents as well as anti-rejection drugs are required, in order to recover the function of the graft.

Keywords

diabetes / pancreas transplantation

References

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