Immunohistochemical analysis of globulin and complements in blood vessels of placental villi during pregnancy induced hypertension

Abstract

The changes of globulin and complements in placental villi blood vessels were immunohistochemically studied in pregnancy induced hypertension patients and normal pregnant patients by a randomized, double-blind approach. The immunostaining of IgG, IgE, C₃, C₄, and 5-HT was seen in the villous blood vessels and the helicine arteries of pregnancy induced hypertensive placental villi. The strong positive rates were 100 %, 90 %, 100 %, 100 % and 90 % in serious pregnancy induced hypertensive patients, accompanied by aggregation of mastocytes and vasculopathy of villous blood vessels and the helicine arteries. It is concluded that the immuno-pathological damage took place in the villous blood vessels and helicine arteries, resulting in vasculopathy and villous regressive changes and that the immunological factors were closely related to pregnancy induced hypertension.

Keywords

pregnancy induced hypertensions immunology / placenta / vasculopathy

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