Immunohistochemical analysis of growth factor expression and localization in gastric coronary vein of cirrhotic patients

Abstract

This study was designed to investigate the expression and localization of PDGF, bFGF, EGF, and TGFα in gastric coronary vein of cirrhotic (n = 30) and non-cirrhotic patients (n = 10) using immunohistochemical technique. The strongly positive immunostaining rate were 93 %, 89 %, 70 % and 68 % respectively in cirrhotic patients. The immunostaining was negative in non-cirrhotic patients. The damage to endothelium, hypertrophy and hyperplasia of vascular smooth muscle cells and vascular remodeling were seen in gastric coronary vein of cirrhotic patients. These results suggested that gastric coronary vein could produce growth factor during cirrhosis, the growth factor can act on the vascular function and/or structure via autocrine-paracrine mechanism.

Keywords

growth factor / gastric coronary vein / cirrhosis

References

[1] 1994,12:760

[2] YangZ, LiuR Ze, YangR Y, et al.. Portal hypertensive vascular lesions. Journal of Tongji Medical University, 1996, 16(1): 32-32

[3] 1996, 13(3):76

[4] KuchanM J, FrangosJ A. Shear stress regulates endothelint release via protein kinase C and cGMP in cultured endathelial cells. Am J Physiol, 1993, 264: H150-H150

[5] DzauV J, GibbonsG H, GookeJ P, et al.. Vascular biology and Medicine in the 1990s, scope, concepts, potentials and perspectives. Circulation, 1993, 87(3): 705-705

[6] ZillaP. The endothelium: a key to the future. J Card Surg, 1993, 8(1): 32-32

[7] DzauV J, KriegerJ E. Molecular biology of hypertension. Hypertension, 1991, 18(3): 1-3

[8] DzauV J, GibbonsG H, MorishitaR, et al.. New perspective in hypertension research. Potentials of vascular biology. Hypertension, 1994, 23: 1132-1132