Immunoregulation of lupus-like NZB/W F₁ mice by antimurine IL-1α, IL-6 antibodies

Abstract

Anti-murine IL-1α, IL-6 antibodies were intra-peritoneally injected to the lupus-like NZB/W F1 mice of 4 months with the dosage of 10 μg per day for three days and then per month for three months. The mice were killed at the age of 11 months. The results showed that the treatment of the dosage could not absolutely prevent lupus nephritis; it could alleviate proteinuria, obviously reduce the levels of serum IL-1α and inhibit the secretion of IL-1α by celiac macrophage. As to the level of IL-6 and TNF-α no significant change was observed.

Keywords

NZB/W F₁ / mouse / anti-IL-1α antibody / anti-IL-6 antibody / immunoregulation

References

[1] 1994, 17(5): 246

[2] JacobC O, VanDer MeideP H, McdevittH O. In Vivo treatment of (NZBxNZW) F₁ Lupuslike nephritis with monoclonal antibody to r interferon. J Exp Med, 1987, 16: 798-798

[3] GordonC, RrngesG E, GreenspanJ S, et al.. Chronic Therapy with Recombinant Tumor necrosis Factor-α in Antoimmune NBZ/W F₁ mice. Clin Immunol Immunopathology, 1989, 52: 421-421

[4] EmmendorfferA, MullerM, WedekindD, et al.. Expansion of the Liver-associated macrophage system in systemic lupus erythematosus-prone NBZ/W mice. J leukoc Biol, 1993, 53(3): 294-294