OxLDL-induced cytotoxicity and its inhibition by API₀₁₃₄ in cultured porcine aortic endothelial cells

Abstract

Protective effects of API₀₁₃₄ on endothelial cells (EC) damaged by oxidatively modified low density lipoprotein (oxLDL) were studied. The results showed that the content of endothelia (ET) and malondialdehyde (MDA) in the media of porcine aortic EC incubated with oxLDL were increased and the cGMP was decreased significantly, and the activity of Superoxide dismutase (SOD) was inhibited. The effect of cytotoxicity of oxLDL can be eliminated by API₀₁₃₄. These results suggest that API₀₁₃₄ may protect EC against damages elicited by oxLDL.

Keywords

API₀₁₃₄ / oxidatively modified low density lipoprotein / endothelial cell

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