Protective effects of API₀₁₃₄ on myocardial ischemia and reperfusion injury

Abstract

Previous studies have demonstrated that a crude extract from Chinese medicinal herbAndrographis Paniculata Nees (APN) could prevent myocardial ischemia and reperfusion injury. A refined extract API₀₁₃₄ was studied further. LAD was ligated for 90 min in 20 dogs and then reperfused for 120 min. The animals were randomly divided into 2 groups, API₀₁₃₄ treated group(n = 10), 45 min after ischemia receiving a slow i. v. bolus of 1 mg/kg and then an infusion of 80 μg D kg⁻¹/min for 60 min and control group (n=10) which was given only 5% glucose in saline. Result showed that the hemodynamics in API₀₁₃₄ treated group showed better effects of preventing the increase of the LVEDP and maintaining relatively normal CO as compared with control group. Ischemic ECGs were significantly milder. Malignant arrhythmia did not appear in API₀₁₃₄ treated group. After reperfusion, the infarct size was smaller (5. 06±2. 67% vs 10. 45±3. 11%,P < 0. 01), the damages found in myocardial ultrastructure were significantly milder. It is concluded that API₀₁₃₄ may protect the myocardium from ischemic reperfusion injury.

Keywords

myocardial reperfusion injury / API₀₁₃₄

References

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