Effects of ligustrazine controlled release capsule in chronic pulmonary heart disease

Abstract

Before and after oral administration of ligustrazine controlled release capsule, pulmonary hemodynamics, right cardiac function, arterial blood gas and TXB₂/6-keto-PGF_1α were studied in 16 patients with advanced cor pulmonale. The decrease of pulmonary arterial pressure and pulmonary vascular resistance, increase of cardiac output, improvement of right cardiac function and arterial blood gas were demonstrated after one course of treatment. The mechanism of these effects may be related to improvement of imbalance of TXB₂/6-keto-PGF_1α. These results were in agreement with those of intravenous administration of ligustrazine, but no adverse reactions were found.

Keywords

pulmonary heart disease / ligustrazine controlled release capsule / pulmonary hemodynamics

References

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