The morphological studies on M2/t(8;21) acute nonlymphocytic leukemia

Abstract

Bone marrow studies including morphological, morphometrical and ultrastructural aspects were performed in 35 patients with M2/t (8;21) and 23 patients with M2/NN. It was found that M2/t (8; 21) patients had higher cellularity in bone marrow. Type (II) myeloblast cells were predominant among myeloblasts. Deformation of nuclei, nucleocytoplasmic asynchronism and dysmegakaryocytopoiesis were more evident in M2/t (8; 21) than in M2/NN patients.

Keywords

M2/t (8;21) acute nonlymphocytic leukemia / morphology / morphometry / ultrastructure

References

[1] BergerR, FlandrinG, BembeimA, et al.. Cytogenetic studies on 519 consecutive De nove acute nonlymphocytic leukemia. Cancer Genet Cytogenet, 1987, 29: 9-9

[2] BergerR, BernbeimA. Ochoanogura M, et al.. Prognostic significance of chromosomal abnormalities in acute nonlymphocytic leukemia; A study of 343 patients. Cancer Genet Cytogenet, 1987, 28: 293-293

[3] BennettJ M, CatovskyD, DanielM T, et al.. Proposed revised criteria for the classification of acute myeloid leukemia. Annals of Int Med, 1985, 103: 626-626

[4] BennettJ M, CatovskyD, DanielM T, et al.. Proposals for the classification of the myelodysplasia syndromes. Bri J Haematol, 1982, 51: 189-189

[5] PearsonE C, WheatlyK. Gray R G, et al.. The significance of ultrastructural features in acute myeloid leukemia: A Study of 220 patients entered into the medical research councils ninth aoute myeloid leukemia trial. Leukemia, 1989, 3: 548-548

[6] BergerR, BernheimA, DanielM T, et al.. Cytologic characterization and significance of normal karyotypes in t (8; 21) acute myeloblastic leukemia. Blood, 1982, 59: 171-171

[7] TricotG, OrshovenA B, DaneleMC, et al.. 8/ 21 Translocation in acute myeloid leukaemia. Scand J Haematol, 1981, 26: 168-168

[8] BillstromR, NilssonP G, MitelmanF. Characteristic patterns of chromosome abnormalities in acute myeloid leukemia with Auer rods. Cancer Gent Cytogenet, 1987, 28: 191-191

[9] OchiaiF, EguchiM. Morphometrical evaluation of acute leukemic cells by electron microscopy. Discrepancy between morphological characteristics in FAB classification and electron, microscopic morphometry. Virchows-Arch-B, 1987, 52: 403-403

[10] TricotG, OrshovenA B, DaneleM C, et al.. 8; 21 translocation in acute myeloid leukemia: An ultrastructure study. Cancer, 1984, 53: 453-453