A chromosome study on 97 cases of acute nonlymphocytic leukemia M2

Abstract

Chromosomal studies were performed in the same laboratory on 97 untreated cases of de novo acute nonlymphocytic leukemia M2. The overall incidence of chromosomal abnormality was 70. 1% (68 out of 97 cases), which was higher in children (84. 2%) than in adults (61%). The male to female chromosomal abnormality ratio was nearly the same (male 71% and female 68.4%,P > 0. 05). Hypodiploidy was the most common numerical abnormality (39%) and t (8; 21) was the most common structural abnormality (48.1%). In the patients with t(8; 21), 64. 5% (20 out of 31 cases) male lost chromosome Y (-Y) and 33% (5 out of 15 cases) female lost one chromosome X (-X).

Keywords

acute nonlymphocytic leukemia M2 / chromosome

References

[1] MitelmanF, HeimS. Quantitative acute leukemia cytogenetics. Genes-Chromosom-Cancer, 1992, 5(1): 57-57

[2] BannettJ M, CatovskyD, DanielM T, et al.. Proposed revised criteria for the classification of acute myeloid leukemia. Annal of Int Med, 1985, 103: 626-626

[3] Fourth international workshop on chromosomes in leukemia. Prospective study of acute nonlynphocytic leukemia. Cancer Genet Cytogenet, 1982, 11: 294

[4] BergerR, FlandrinG, BernheimA, et al.. Cytogenetic studies on 519 consecutive de novo acute nonlymphocytic leukemias. Cancer Genet cytogenet, 1989, 29: 9-9

[5] BergerR, BernheimA, OchoanoguraM E, et al.. Prognostic significance of chromosomal abnormalities in acute nonlymphocytic leukemia, A study of 343 patients. Cancer Genet Cytogenet, 1987, 28: 293-293

[6] ShikanoT, NaitoH, KobayashiR, et al.. Cytogenetc study on 53 childhood auete nonlymphocytic leukemia. Rinsho-Ketsueki, 1991, 32: 766-766

[7] Second MIC cooperative study group (1986). Morphologic, immunologic, and cytogenetic (MIC) working classification of the acute myeloid leukemias. Cancer Genet Cytogenet, 1988, 30: 1-1

[8] PetkovicI, KonjaJ, NakicM. Cytogenetic analysis in children with acute nonlymphocytic leukemia. Cancer Cyenet Cytogenet, 1992, 58: 155-155

[9] FenauxP, PreudhommeC, LaiJ L, et al.. Cytogenetics and their pregnostic value in de novo acute myeloid leukaemia. A report on 283 cases. Br J Haematology, 1989, 73: 61-61