Expression of multidrug-associated protein, P-glycoprotein, P53 and Bcl-2 proteins in bladder cancer and clinical implication

Abstract

The expression of multidrug resistant proteins in bladder cancer and clinical implication was studied. Expression of multidrug-associated protein (MRP), P-glycoprotein (P-gp), P53 and Bcl-2 proteins were detected by using immunohistochemical method in 40 specimens of bladder transitional cell carcinoma. The results showed that the positive rate of MRP, P-gp, P53 and Bcl-2 was 52. 5 %, 57. 5 %, 47. 5 % and 62. 5 % respectively. The positive rate of MRP, P-gp, P53 and Bcl-2 in the grade I, I andI of tumors was 46. 3 %, 38. 5 %, 38. 5 %, 23. 1 %; 52. 9 %, 39. 8 %, 47. 1 %, 76. 4 %; 60. 0 %, 80. 0 %, 60. 0 %, 90. 0 % respectively. The positive rate of MRP, P-gp, P53 and Bcl-2 in 24 primary tumor specimens was 37. 5 %, 41. 7 %, 33. 3 %, 45. 8 % and that in 16 cases in recurrent specimens receiving chemotherapy 75. 0 %, 81. 3 %, 68. 8 %, 87. 5 % respectively. It was suggested the positive rate of MRP, P-gp, P53 and Bcl-2 was increased with the advance of tumor grade. The positive rate of four proteins in all recurrent cases was significantly increased (P<0. 05). The expression of MRP, P-gp, P53 and Bcl-2 proteins might be the important factors for chemotherapy failure.

Keywords

bladder neoplasms / multiple drug resistance / apoptosis

References

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