Studies on metal phthalocyanine as a dual functional mimic enzyme

Abstract

Four phthalocyanines (iron tetracarboxylphthalocyanine, copper tetracarboxylphthalocyanine, manganese tetracarboxylphthalocyanine, cobalt tetracarboxylphthalocyanine) were used as dual functional mimic enzymes of Superoxide dismutase (SOD) and catalase (CAT). The first function, eliminating O₂^-, was proved by using riboflavine-methionine photoreduction method in the concentration range of 10^-5 to 10^-6 mol/L. The second function, clearing out H₂O₂, was demonstrated by means of spectrophotometry with the decomposing percentage being increased with the increase of the concentration of the imitating compounds. Measurements of metal phthalocyanines, SOD and CAT by the liver homogenate technique of mice showed that they had obvious action of decreasing the lipid peroxidation.

Keywords

metal phthalocyanines / Superoxide dismutase / catalase / lipid peroxidation

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