Effect of domestically-made levonorgestrel-releasing intrauterine device on the endocrine system and mensentruation in monkeys

Abstract

Effect of domestically-made levonorgestrel-releasing intrauterine device (LNG, release rate: 6 μg/day) on the endocrine system and menstruation in mondeys was investigated. The results showed that the Estradiol (E₂) and progesterone (P) levels were significantly decreased 2 ovulatory cycles after insertion of the devices as compared with those before insertion in 3 monkeys (P> 0. 001), suggesting an evident ovulation-suppressing effect. In 1 monkey, the E₂ and P levels were the same before and after insertion, and expulsion of device was found in the monkey later. The plasma LNG concentration in 3 animals was 493. 69–454. 60 pg/ml and plasma LNG was not detected in 1 monkey. The hormone level returned to normal level after removal of the devices.

Keywords

levonorgestrel / intrauterine device / endocrine system

References

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