Effect of captopril on membrane currents of ventricular myocytes

Abstract

Using whole-cell patch-clamp technique, the present studv examined the effects of captopril on membrane currents of ventricular myocytes. The re suits were as follows: when the concentration of captopril was 6× 10⁻⁴ mol the fast inward sodium current and slow inward calcium current were all decreased significantly (P <0. 05). Besides, when the concentration exceeds 10⁻³ mol, the delayed rectifier potassium current was increased (P <0. 05) as well But if the experimental concentration was under 6 × 10⁻⁴ mol, these three kinds of currents was not affected. These findings suggested that captopril has no direct antiar rhythmic effect at the average therapeutic serum level.

Keywords

captopril / patch clamp / ion channels

References

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