An experimental study of the mechanism of andrographis paniculata nees (APN) in alleviating the Ca²⁺-overloading in the process of myocardial ischemie reperfusion

Abstract

The aim of this experiment is to study the mechanism of APN in alleviating the Ca²⁺-overloading in dog model during the process of ischemic reperfusion. In comparison with the sustained ischemic group, the parameters in the ischemic reperfusion group demonstrated: Ca²⁺ of ischemie region of myocardial cell increased (P<0. 05). Na⁺ increased remarkablyP<0. 01), the activity of Ca²⁺-ATPase dropped remarkably (P<0. 01),and MDA increased significantly (P<0. 01). Whereas in the group pretreated with APN, the Ca²⁺ in the relevant area reduced (P<0. 05), Na⁺ decreased significantly (P<0. 01), the activity of Ca²⁺-ATPase and Na⁺-K⁺ ATPase increased remarkably (P<0. 01), and MDA decreased significantly (P<0. 01). These findings indicate that APN may improve the activity of sarcolemma ATPase in alleviating the Ca²⁺ and Na⁺-overloading by decreasing the harmful effect of oxygen free radicals.

Keywords

myocardial ischemia reperfusion / andrographis paniculata Nees (APN) / calcium

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