Study of HCV infection and viremia in patients with posttransfusion hepatitis in China

Abstract

One hundred and sixty-nine patients with posttransfusion hepatitis (PTH) were investigated for etiology with serological and PCR methods. Our result showed that HCV was the major causative agent of PTH in this study. A part of patients (24/169) were also HBV markers positive. Three patients were negative for all detected viral markers, looking forwards to progressive study. Anti-HCV was detectable from 7 days to one year after onsetting of clinical symptoms, average time 54. 62 days. HCV RNA could be detected in early time of HCV infection (6 to 20 days later), average time 8. 72 days. A follow-up study of 84 patients showed that all patients remained anti-HCV positive during the observation for 1. 5-3 years, but their HCV viremia had three forms: transient, persistent or intermittent. The interaction between HCV and HBV by their superinfection was unknown, awaiting further study.

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