The change of T lymphocytsubpopulations, interleukin-2 receptor and HLA-DR antigen in lupusnephritis patients

Abstract

In this study peripheral blood mononuclear cells were tested for T lymphocytsubpopulations, interleukin-2 receptor (IL-2R) and HLA-DR antigen by monoclonal antibodies in 14 LN patients. In comparison with normal controls, 14 LN patients showed a decrease of T₄ lymphocyte (0.01<P<0.05) and increase of T₈ cells (P<0.01) with reduction of T₄/T₈ ratio (P<0.0l). The expression of HLA-DR cells increased (P<0.0l), the expression of IL-2R activited by PHA significantly decreased (P<0.0l), while nonactivited IL-2R expression significantly increased (P<0.01). T₄/T₈ ratio was significantly correlated with activited IL-2R expression (P<0.01, r = 0.6599). The results indicated that there was a immunological defect in LN patients. The pathogenesis of LN might be heterogeneous.

References

[1] RobertN, et al.. Lymphocyte subpopulations in patients with systemic lupus erythematosus. Clin Immunol Immunopathol, 1984, 3l: 181-190

[2] MorimotoC. Loss of suppressor T-lymphocyte function in patients with systemic lupus erythematosus. Clin Exp Immunol, 1987, 32: 125-33

[3] RaziuddinS, et al.. OKT₄ cell abnormality in patients with active systemic lupus erythematosus: HLA-DR antigen expressions. Clin Immunol Immunopathol, 1988, 48: 42-49

[4] RolandCranow R, et al.. Pan-T, T₄- und T₈-positive Lymphozyten mit systemischem Lupus erythematodes. Z gesamte Inn Med, 1987, 42: 130-134

[5] SmolenJ S, et al.. Heterogeneity of immunregulatory T cell subsets in systemic lupus erythematosus: Correlation with clinical features. Am J Med, 1982, 72: 783-790

[6] BakkeA C, et al.. T lymphocyte subsets in syscemic lupus erythematosus. Arthritis Rheum, 1983, 26: 745-750

[7] Unanue ER, Benacerraf B. Textbook of Immunology. 2ed. Baltimore Williams & Wilkins: 1984; 167.

[8] Ten BergeR J M, et al.. Administration of prednisone in vivo affects the ratio of OKT₄/OKT₈ and the LDH-isoenzyme pattern of human T-lymphocyte. Clin Immunopathol, 1984, 30: 91-97

[9] GuptaS, et al.. Immunology of rheumatic disease, 1985Wuhan, LondonPlenum Medical Book Company21-85

[10] JacksonA L, et al.. Restricted expression of p55 interleukin 2receptor(CD₂₅) on normal T cell. Clin Immunol Immunopathol, 1990, 54: 126-133

[11] DamleN K, et al.. Autologous mixed lymphocyte reactions in man: V. Functionally and phenotypically distinct human T cell subpopulation respond to non-T and activated T cell in AMLR. Scand J Immunol, 1982, 16: 59-63

[12] RaziuddinS, et al.. Increased circulating HLA-DR⁺, CD₄⁺ T cell in systemic lupus erythematosus. Associated with prednisolone therapy. Scand J Immunol, 1990, 31: 139-145