Effect of Huoxuequyu recipe on erythrocyte membrane Ca²⁺-ATPase activity in pregnant rats with asymmetrical intrauterine growth retardation induced by passive smoking

Abstract

The effect of Huoxuequyu recipe on erythrocyte membrane Ca²⁺-ATPase activity in pregnant rats with passive smoking induced asymmetrical intrauterine growth retardation (IUGR) was observed. The rats were divided into three groups: control group, model group and treated group. The fetal mean birth weight and erythrocyte membrane Ca²⁺-ATPase activity were found to be decreased in the model group as compared with the control and treated groups. There was a significant difference between the model group and the control group (P<0.01), while no significant difference existed between the treated group and the control group (P>0. 05). Furthermore, the findings indicated that the erythrocyte membrane Ca²⁺-ATPase activity seem to be positively correlated with the birth weight (P<0. 05).

On the basis of our observation, it is believedthat the Huoxuequyu decoction could increase erythrocyte membrane Ca²⁺-ATPase activity and promote blood circulation, thereby exerting a beneficial effect on fetal development.

Keywords

smoking / erythrocyte membrane / Ca²⁺-ATPase / Huoxuequyu recipe / IUGR

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