Effects of 3,4 - dihydroxyacetophenone (3,4-DHAP) on hypoxic pulmonary and systemic vascular response in dogs

Abstract

The effects of 3,4-DHAP on hypoxic pulmonary and systemic vascular responses were studied in anaesthetized dogs. The percentage change in pulmonary vascular resistance (Δ PVR %) and that in systemic vascular resistance (Δ SVR %) induced by 5 min hypoxia decreased significantly. 3,4-DHAP in doses of 1 mg/kg, 3 mg/kg, and 10 mg/kg i. v caused a decrease in Δ PVR% from the control value of 47.27±22.27 % to 24.62±21.76 %, 18–15±18.73 %, and 24.10 ±19. 76 % respectively, and a decrease in Δ SVR % from the control value of 12. 91 ±7. 39 % to-0. 34±12. 70 %, −2.11 ±12. 76 %, and -2.37±15. 52 % respectively. The results showed that 3,4-DHAP could decrease the hypoxic responses of pulmonary and systemic blood vessels. But it did not change Δ PVR % or Δ SVR % in dose of 30 mg/kg, neither did it influence the heart rate, cardiac output or cerebral blood flow during hypoxia in all the doses used.

Keywords

3,4 - dihydroxyacetophenone / pulmonary circulation / systemic circulation / hypoxia

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