A comparative experimental study on primary and secondary nerve grafting following inferior alveolar nerve injury

Abstract

The damaged inferior alveolar nerve of rabbit was repaired with autogenous ipsilateral greater auricular nerve grafting primarily and secondarily, and electrophysiological, ultrastructural, microvascular and histochemical investigations ] were performed in this study. The results indicated that the experimental effects of group 1 out of 3 groups (group 1 with immediate grafting, group 2 with grafting after 4 weeks, and group 3 with grafting after 8 weeks) were the best and those of group 2 were second only to group 1 with no obvious difference between these two groups (P>0.05). However, the results of group 3 were not good enough, and there was significant difference from the other two groups (P<0.05). Therefore, we were led to conclude that the injury should be repaired at once or within 4 weeks after inferior alveolar ne.rve was damaged, or within 2 or 3 months thereafter, to improve the function of the injured nerve as greatly as possible.

Keywords

nerve grafting / inferior alveolar nerve

References

[1] GodfreyRM, et al.. Somatosensory evoked potentials to electrical stimulation of the mental nerve. Br J Oral Maxillofac Surg, 1987, 25: 300-7

[2] NomaH, et al.. Repair of the mandibular nerve by autogenous grafting after partial resection of the mandible. J Oral Maxillofac Surg, 1986, 44: 31-6

[3] UptonLG, et al.. Evaluation of the regenerative capacity of the inferior alveolar nerve following surgical trauma. J Oral Maxillofac Surg, 1987, 45: 212-6

[4] HatanoE. A comparative study on primary and secondary nerve repair. Plast Reconstr Surg, 1981, 68: 760-7

[5] WessbergGA, et al.. Simultaneous inferior alveolar nerve graft and osseous reconstruction of the mandible. J Oral Maxillofac Surg, 1982, 40: 384-90

[6] BrayGM, et al.. Regeneration of peripheral unmyelinated nerves fate of axonal sprouts which develop after injury. J Anat, 1974, 117: 517-29

[7] KristenssonK, et al.. Axonal uptake and retrograde transport of exogenous proteins in the hypoglossal nerve. Brain Res, 1971, 32: 399-405

[8] TyndallDA, et al.. Evaluation of peripheral nerve regeneration following crushing or transection injuries. J Oral Maxillofac Surg, 1984, 42: 314-8

[9] WessbergGA, et al.. Bilateral microneurosurgical reconstruction of inferior alveolar nerve via autogenous sural nerve transplantation. Oral Surg, 1981, 52: 465-70

[10] MeyerV, et al.. Primary and secondary reconstruction of peripheral nerve lesion. Plast Reconstr Surg, 1980, 65: 383-383