Cordyceps Sinensis-I as an immunosuppressant in heterotopic heart allograft model in rats

Abstract

To investigate the inhibitory effects of Cordyceps Sinensis-I (CS-1) on the immune response responsible for the organ transplant rejection, we studied its effects of prolonging heterotopic heart allograft survival on rat model with heart graft; the effects of CS-1 were compared with those of cyclosporine A and glucocorticoid, and the possible pathological changes caused by CS-1 were observed. Our results showed that CS-1 can prolong the survival of grafted heart without causing infection, and it did not exert detrimental effects on vital organs. As a result, it proves to be a promising immunosuppressant in clinical organ transplantation in the future.

Keywords

Cordyceps Sinensis / heterotopic heart transplantation / immunosuppressant

References

[1] OneK, et al.. Improved technique of heart transplantation in rat. J Thorac Cardiovasc Surg, 1969, 57: 225-7

[2] LeeS, et al.. A simplified model for heterotopic rat heart transplantation. Transplantation, 1982, 33: 438-40

[3] 1983; 10(2): 95–6.

[4] 1984; 9(4): 248–50.

[5] IV. 1988;17(5): 329–31.

[6] V. 1988; 17(5): 332–4.

[7] MayumiH, et al.. Drug-induced tolerance to allografts in mice: V. Prolongation of skin graft survival in tolerant mice with combined immunosuppressive treatments. Transplantation, 1985, 39: 335-8