Effects of acute ingestion of ethanol on hemodynamics and hypoxic pulmonary vasoconstriction in dogs—Role of leukotrienes

Abstract

The effects of acute intragastric administration of ethanol on hemodynamics and hypoxic pulmonary vasoconstriction were studied in spontaneously breathing dogs. The dogs were given 0.5 g/kg of 10 % ethanol (v/v) in 5 min. Hemodynamic measurements were obtained before and 30 min after ingestion of ethanol. Mean pulmonary arterial pressure and pulmonary vascular resistance increased markedly after ingestion of ethanol, and hypoxic pulmonary vasoconstriction was augmented significantly by ethanol as well. Diethylcarbamazine citrate (DEC), a lipooxygenase inhibitor, inhibited these effects of ethanol in a dosage of 200 mg/kg. The above findings suggest that ethanol can induce pulmonary vasoconstriction, which may be predominantly mediated by leukotrienes (LTs).

Keywords

ethanol / hypoxia / pulmonary circulation

References

[1] DrummondWH, et al.. Ethanol induces acute pulmonary vasoconstriction in salt-perfused rat lungs. Exp Lung Res, 1989, 15(3): 447-447

[2] DrummondWH, et al.. Cyclooxygenase blockers inhibit ethanol-induced pul-monary vasoconstriction in lambs. J Appl Fhysiol, 1989, 66(2): 822-822

[3] KoskinenP, et al.. Effects of alcohol on systemic and palmonary hemodyna-mics in normal humans. Clin Cardiol, 1986, 9(10): 479-479

[4] DrummondWH, et al.. Ethanol induc-ed dose-dependent vasoconstriction in unanesthetized lambs. Exp Lung Res, 1985, 9(3-4): 341-341

[5] KettunenR, et al.. Influence of etha-nol on systemic and pulmonary hemo-dynamics in anesthetized dogs. Acta Physiol Scand, 1983, 118(3): 209-209

[6] ChengCP, et al.. Acute effects of mildly intoxicating levels of alcohol on left ventricular function in con-scious dogs. J Clin Invest, 1990, 85(6): 1858-1858

[7] AhonenE, et al.. Combined effect of low doses of proprarolol and ethanol on cardiac function: a comparative study by radionuclide ventriculography in conscious dogs. Pharmacol Toxicol, 1987, 61(1): 33-33

[8] MorvaiV, et al.. Acute effecis of low doses of alcohol on the cardiovascular system in young men. Acta Med Hung, 1988, 45(3-4): 339-339

[9] RogersPJ, et al.. Epicardial coronary artery constriction with intravenous ethanol. Int. J Cardiol, 1989, 22(3): 301-301

[10] HayesSN, et al.. Ethanol causes epi-cardial coronary artery vasoconstric-tion in the intact dogs. Circulation, 1988, 78(1): 165-165

[11] RheeHM, et al.. Vascular responses to vasoactive agents in dietary alcohol-treated rats. Clin Exp Pharmacol Phy-siol Suppl, 1989, 15: 129-129

[12] BurkeWolin TM, et al.. Inhibition of cGMP-associated pulmonary arterial relaxation to H202 and 02 by ethanol. Am J Physiol, 1990, 258: H1267-H1267

[13] HannaCJ, et al.. Slow-reacting subs-tances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro. Nature, 1981, 290: 343-343

[14] MorganrothML, et al.. Leukotrienes C4 production during hypoxic pulmonary vasoconstriction in isolated rat lungs. Prostaglandins, 1984, 28: 867-867