Local inhibition of chlorhexidinum on lewis pulmonary carcinoma in mice

Abstract

C⁵⁷ inbred mice (n=100) were employed to develop animal models of Lewis pulmonary carcinoma. The study on the tumor inhibition was performed by infiltrative injection of 3.5% Cy or chlorhexidinum of two different concentrations around the tumor respectively. The suryival, survival rate, tumor growth rate, and pulmonary metastasis node number were compared. The results showed that the inhibitory effects of 0.1% and 0.5% chlorhexidinum were the same as that of 3.5% Cy, but the toxic and side effects were obviously reduced as compared with 3.5% Cy. The optimal concentration of chlorhexidinum was 0.5%. This provides a new approach for infiltrative injection of the tumor for clinical use.

Keywords

chlorhexidinum / Lewis pulmonary carcinoma

References

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