Tumor necrosis factor expression in arterial walls of diabetic rats

Abstract

Immunohistochemistry was used to detect tumor necrosis factor (TNF-α) expression in arterial wall of diabetic rats. It was found that endothelial cells were swollen and markedly proliferative in these vessels and accordingly TNF-α showed strong positive immunohistochemical reaction in endothelial cells qr extracellular intimai matrix of such vessels, which might be caused by the expression and release of TNF-α from monocytes and arterial wall cells stimulated by AGEs. These findings suggested that increased TNF-α expression might be associated with vascular damage and remodeling in diabetes.

Keywords

diabetes mellitus / endothelial cell / proliferation / tumor necrosis factor

References

[1] BeutlerB A, CeramiA. The biology of Cachectin/TNF-α primary mediator of the host response. Annu Rev Immunol, 1989, 7: 625-625

[2] SherryB, CeramiA. Cachectin/TNF exerts endocrine, paracrine and autocrine control of inflammatory response. J Cell Biol, 1988, 107: 1269-1269

[3] RusH G, NiculescuF, VlaicuR. Tumor necrosis factor alpha in human arterial wall with atherosclerosis. Atherosclerosis, 1991, 89: 247-247

[4] WarnerS J C, LibbyP. Human vascular smooth muscle cells target for and source of TNF. J Immunol, 1989, 142: 100-100

[5] NawrothP P, SternD M. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med, 1986, 163: 740-740