Relationship between the expression of α1-antitrypsinase in bronchioalveolar carcinoma and clinical pathology

Abstract

By using immunohistochemistry LSAB method and imaging analysis technique, the expression of α1-antitrypsinase (α1-AT) in 41 cases of bronchioalveolar carcinoma (BAC) was quantitatively detected to explore the relationship between α1-AT expression in BAC tissues and clinical pathology. The results showed that the total positive rate for α1-AT expression was 85. 4 %. The positive rate for α1-AT expression in alveolar BAC was 100 %, with the immunity reactive staining intensity being significantly higher than in papillary BAC, mucinous BAC or sclerosing BAC (P < 0. 05). The positive rate in papillary BAC was 93. 3 %, with the intensity higher mucinous BAC or sclerosing BAC (P < 0. 01); The positive rate in both mucinous BAC and sclerosing BAC was 66.7 % (P > 0. 05); The expression intensity in lymph node metastatic group was obviously lower than that in the group without metastasis (P < 0.01); The patients with mucinous BAC were diagnosed at a younger age than those with other histologic types of BAC (P < 0.05). It was suggested that BAC cells could also produce α1-AT. Detection of α1-AT could be used as a new method to diagnose BAC and might play a role in assessing BAC metastasis.

Keywords

bronchioalveolar carcinoma / α1-antitrypsinase / immunohistochemistry / imaging analysis

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